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Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM heads preferance. (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.

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Pgnancy: Tatognic cts : Pgnancy Catgoy C. poductiv studis hav bn pomd in ats and abbits at doss up ttwnty tims th usual human dos (5 mg/kg p day), and it was concludd that th was nimpaid tility ham tth tus du tallopuinol. Th is a publishd pot a study in pgnant mic givn 50 100 mg/kg allopuinol intapitonally on gstation days 10 13. Th w incasd numbs dad tuss in dams givn 100 mg/kg allopuinol but not in thos givn 50 mg/kg. Th w incasd numbs xtnal malomations in tuss at both doss allopuinol on gstation day 10 and incasd numbs skltal malomations in tuss at both doss on gstation day 13. It cannot b dtmind whth this psntd a tal ct an ct sconday tmatnal toxicity. Th a, howv, nadquat wll-contolld studis in pgnant womn. Bcaus animal poduction studis a not always pdictiv human spons, this dug should b usd duing pgnancy only i claly ndd.

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